Enrichment of interleukin-2-responsive natural killer progenitors in human bone marrow
نویسندگان
چکیده
منابع مشابه
Natural killer cell-mediated eradication of neuroblastoma metastases to bone marrow by targeted interleukin-2 therapy.
Targeted interleukin-2 (IL-2) therapy with a genetically engineered antidisialoganglioside GD2 antibody-IL-2 fusion protein induced a cell-mediated antitumor response that effectively eradicated established bone marrow and liver metastases in a syngeneic model of neuroblastoma. The mechanism involved is exclusively natural killer (NK) cell-dependent, because NK-cell deficiency abrogated the ant...
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Ex vivo expansion of human umbilical cord blood cells (HUCBC) is explored by several investigators to enhance the repopulating potential of HUCBC. The proliferation and expansion of human hematopoietic stem cells (HSC) in ex vivo culture was examined with the goal of generating a suitable clinical protocol for expanding HSC for patient transplantation. Using primary human mesenchymal stem ...
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We have adapted the stroma-dependent long-term bone marrow culture (LTBMC) system to study the development of human natural killer cells (NK) from the CD34+/HLA-DR- (CD34+/DR-) BM mononuclear cell (BMMNC) population. The CD34+/DR- population does not express any known antigens associated with myeloid or lymphoid lineage and has been shown by us and others to contain primitive hematopoietic prog...
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By using human bone marrow cells enriched for early progenitors by selective immunoadsorption and plated at low cell density (iO to iO cells/mL/9.6 cm2) in semisolid methylcellulose culture. we have analyzed the cooperative effects of human colony-stimulating factor 1 (CSF-1 ), granulocyte-macrophage-CSF (GM-CSF). interleukin-1 a (ILla). and gibbon as well as human recombinant IL-3 on the forma...
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ژورنال
عنوان ژورنال: Blood
سال: 1993
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.v81.7.1819.bloodjournal8171819